Question: Discuss consid............. Edit
Answer: Gene silencing is a general term used to describe the epigenetic regulation of gene expression. In particular, this term refers to the ability of a cell to prevent the expression of a certain gene. Gene silencing can occur during either transcription or translation and is often used in research. In particular, methods used to silence genes are being increasingly used to produce therapeutics to combat cancer and diseases, such as infectious diseases and neurodegenerative disorders.
Gene silencing is often confused with gene knockout. Though gene silencing is the same as gene knockdown, it is different from gene knockout. When genes are knocked down, their expression is reduced. In contrast, when genes are knocked out, they are completely erased from the organism's genome and, thus, have no expression. Gene silencing is considered a gene knockdown mechanism since the methods used to silence genes, such as RNAi, generally reduce the expression of a gene by at least 70% but do not completely eliminate it.
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